Unbranded, secure packaging guaranteed
When you sign up
Genuine pet medicine
One chew. Once a month. Complete protection.
Simparica Trio is the only monthly flea, tick and worm treatment for dogs that combines three active ingredients in a single chewable dose. It protects your dog from:
As a bonus, rapid flea elimination also reduces the risk of flea tapeworm (Dipylidium caninum) infestations.
This item requires a current prescription from your vet before we can dispatch it. The good news? Sorting it out is simple and only takes a moment.
As soon as your prescription reaches us, our team will verify the details and get your pet’s treatment posted out to you.
One chew. Once a month. Complete protection.
Simparica Trio is the only monthly flea, tick and worm treatment for dogs that combines three active ingredients in a single chewable dose. It protects your dog from:
As a bonus, rapid flea elimination also reduces the risk of flea tapeworm (Dipylidium caninum) infestations.
This product cannot be dispatched without a valid written prescription from a registered veterinary surgeon.
Simparica Trio Chewable Tablets for Dogs are a broad-spectrum monthly parasite treatment combining three active ingredients — sarolaner, moxidectin, and pyrantel embonate — in a single palatable tablet. This precise formulation delivers an all-in-one internal and external parasite routine in a single chew.
One tablet simultaneously covers external parasites (fleas, ticks, and mites) and internal parasites (roundworms, hookworms, lungworm, and heartworm). For dog owners managing multiple parasite risks, that means fewer products, simpler routines, and no missed doses.
Simparica Trio is prescribed for dogs suffering from, or at risk from, mixed external and internal parasitic infestations. It is indicated when treatment against ticks, fleas or mites and gastrointestinal worms is needed at the same time. If your dog only requires flea and tick protection without intestinal worm or lungworm coverage, standard Simparica is typically prescribed instead. The tablets are reddish-brown, highly palatable, and easy to give by hand or mixed into food. Do not divide or split the tablets.
Simparica Trio Ingredients: Sarolaner, Moxidectin, Pyrantel Embonate
Legal Category: AVM-GSL
View the Summary of Product Characteristics (SPC) information for this product
Administer one chewable tablet by mouth once a month, ideally on the same date. Any repeat doses must follow a minimum one-month interval.
The tablet can be offered directly by hand as a treat or hidden inside a small portion of food. Ensure the dog swallows the entire tablet to guarantee a full dose.
If a monthly dose is missed, administer the tablet as soon as you remember, and reset your regular monthly schedule from that specific date forward.
Never double up or administer two tablets at once to compensate for a missed dose.
Wash your hands after handling the product, and return the blister pack to the carton after use, storing it out of the sight and reach of children.
Do not use in cases of known hypersensitivity to sarolaner, moxidectin, pyrantel, or any of the product’s inactive excipients.
Use in puppies under 8 weeks of age, or in dogs weighing less than 1.25 kg, is not recommended unless your vet has carried out a specific benefit-risk assessment.
Not recommended for use during pregnancy, lactation, or in dogs intended for breeding, as safety during these stages has not been clinically established.
Use with caution in dogs with a known MDR1 (multidrug-resistance protein 1) gene deficiency, such as Collies and related herding breeds. The recommended weight-based dose must be strictly observed in these animals.
Tell your vet about any other medicines your dog is taking. Certain medicines that inhibit p-glycoprotein (such as cyclosporine, ketoconazole, spinosad, or verapamil) should only be used alongside Simparica Trio if your vet judges the benefit outweighs the risk.
Simparica Trio prevents heartworm disease but is not effective against adult heartworms (Dirofilaria immitis). Dogs living in, or returning from, heartworm-endemic areas should be tested by a vet before starting preventative treatment — only dogs that test negative should be treated.
This medicine is exclusively formulated for dogs. Do not administer to cats or any other animal species.
Simparica Trio sizes are matched to six weight ranges, each meticulously aligned to a specific canine body weight. Your vet will confirm the exact tablet strength required on your prescription. The table below is for customer reference:
| Dog Weight Class | Chewable Tablet Strength (Sarolaner / Moxidectin / Pyrantel) | Available Pack Sizes |
| 1.25 kg – 2.5 kg | 3 mg / 0.06 mg / 12.5 mg | Pack of 3 or 6 |
| >2.5 kg – 5 kg | 6 mg / 0.12 mg / 25 mg | Pack of 3 or 6 |
| >5 kg – 10 kg | 12 mg / 0.24 mg / 50 mg | Pack of 3 or 6 and 10 x pack of 3 |
| >10 kg – 20 kg | 24 mg / 0.48 mg / 100 mg | Pack of 3 or 6 and 10 x pack of 3 |
| >20 kg – 40 kg | 48 mg / 0.96 mg / 200 mg | Pack of 3 or 6 and 10 x pack of 3 |
| >40 kg – 60 kg | 72 mg / 1.44 mg / 300 mg | Pack of 3 or 6 |
Note: For dogs weighing over 60 kg, an appropriate combination of tablet strengths must be used under strict veterinary direction. To ensure correct dosing, your dog’s body weight should be determined as accurately as possible.
Select the treatment you would like to order
Provide all the information about your pet
Your order will be sent in discreet packaging.
Yes. POM-V items require a valid prescription from your UK vet.
Upload your prescription during checkout.
Photos must be clear. If details are wrong or expired, orders can’t be processed. This is standard across UK pet pharmacies.
No. Under UK law, vets must provide a written prescription if you request one for a POM-V medicine. They may charge a reasonable fee for issuing it, but they cannot refuse. This allows you to choose where to buy your pet’s medication, whether directly from your vet or from a registered UK pharmacy such as Ashcroft 4 Pets.
In the UK, most POM-V prescriptions are valid for 6 months, unless your vet specifies a shorter duration. Prescriptions for Schedule 2 or 3 controlled medicines are usually valid for 28 days and are not repeatable. At Ashcroft 4 Pets, we follow these same UK veterinary guidelines to ensure your pet’s medication is dispensed safely and legally.
At Ashcroft 4 Pets, we are a fully VMD-registered and accredited online retailer. This means every prescription and over-the-counter pet medicine we supply is safe, genuine, and dispensed according to UK law.
We follow all Veterinary Medicines Directorate (VMD) rules, and our team checks every prescription carefully before processing. You can order with confidence, knowing your pet’s health is in the hands of experts and all medicines are traceable, legally supplied, and authentic.
In the UK, most repeat prescriptions for POM-V medicines are valid for up to 6 months from the date your vet issues them. You can order multiple times within this period if your vet has authorised repeats.
For controlled medicines (Schedule 2 or 3), the prescription is valid for 28 days only and cannot be repeated. These medicines are strictly regulated due to their potential for misuse.
At Ashcroft 4 Pets, we follow UK law carefully, ensuring all prescriptions are dispensed safely, legally, and in the exact amounts prescribed.
If your vet prescribes a human medicine for your pet under the Cascade, we can usually dispense against that prescription (with the right checks).
Home/Pet Advice/Fleas & Ticks/How Long Does Flea Treatment Take to Work? Timing Guide Fleas & Ticks How Long Does Flea Treatment Take to Work? Timing Guide Reviewed by Dr Brian Faulkner, BVetMed MRCVS Clinical Lead, Ashcroft 4 Pets · RCVS
Home/Pet Advice/Worms/How Often Does a Dog Need Worming? Vet Schedule UK Worms How Often Does a Dog Need Worming? Vet Schedule UK Reviewed by Dr Brian Faulkner, BVetMed MRCVS Clinical Lead, Ashcroft 4 Pets · RCVS Reg. 7041592 Verified Updated
Home/Pet Advice/Fleas & Ticks/Best Flea Treatment for Dogs UK Fleas & Ticks Best Flea Treatment for Dogs UK: How to Choose the Right Option Reviewed by Dr Brian Faulkner, BVetMed MRCVS Clinical Lead, Ashcroft 4 Pets · RCVS Reg. 7041592
